Synthesis of polysubstituted cyclopenta[b]indoles via relay gold(I)/Brønsted acid catalysis.
نویسندگان
چکیده
An efficient relay catalytic process involving Au(i)/Brønsted acid to access various polysubstituted cyclopentannulated indoles from easily accessible 1-(2-aminophenyl)prop-2-ynols and readily available 1,3-dicarbonyls has been developed. In an unprecedented event, the intermediate 2-indolylmethyl cations undergo the cation-Ene reaction with various 1,3-dicarbonyls followed by an intramolecular Friedel-Crafts-type reaction generating functionalized cyclopenta[b]indoles.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 3 شماره
صفحات -
تاریخ انتشار 2015